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Carboplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks when used at concentrations of 200 and 300 µM. It inhibits the proliferation of GLC-4 small cell lung carcinoma and A2780 and SKOV3 ovarian cancer cells (IC50s = 22.7, 0.5, and 10.2 µM, respectively). Carboplatin reduces tumor growth in an ADJ/PC6 murine plasmacytoma model (ED90 = 0.6 mg/kg, i.p.). Formulations containing carboplatin have been used in the treatment of ovarian cancer.Formal Name: (SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2-)-kappaO,kappaO'']-platinum. CAS Number: 41575-94-4. Synonyms: CBDCA, CDDCA, cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II), NSC 201345, NSC 241240. Molecular Formula: C6H12N2O4Pt. Formula Weight: 371.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 1 mg/ml. SMILES: O=C([O-][Pt+2]1([NH3])[NH3])C2(CCC2)C([O-]1)=O. InChi Code: InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6,,,/h1-3H2,(H,7,8)(H,9,10),2*1H3,/q,,,+2/p-2. InChi Key: OLESAACUTLOWQZ-UHFFFAOYSA-L.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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