Calycosin 7-O-beta-D-Glucoside

Calycosin 7-O-beta-D-glucoside is an isoflavone glycoside that has been isolated from A. mongholicus and A. membranaceus and has antioxidant, anti-inflammatory, and neuroprotective biological activities. It scavenges 34.5% of generated 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals compared to a vehicle control when used at a concentration of 100 µg/ml in a cell-free assay. Calycosin 7-O-beta-D-glucoside (10 µg/ml) inhibits cytotoxicity, intracellular reactive oxygen species (ROS) production, and cytoskeletal defects induced by LPS in human umbilical vein endothelial cells (HUVECs). In vivo, calycosin 7-O-beta-D-glucoside (26.8 mg/kg) reduces brain infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).Formal Name: 7-(beta-D-glucopyranosyloxy)-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 20633-67-4. Molecular Formula: C22H22O10. Formula Weight: 446.4. Purity: >98%. Formulation: (Request formulation change), A lyophilisate. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml. lambdamax: 221, 261 nm. SMILES: O=C1C2=CC=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C=C2OC=C1C4=CC(O)=C(OC)C=C4. InChi Code: InChI=1S/C22H22O10/c1-29-15-5-2-10(6-14(15)24)13-9-30-16-7-11(3-4-12(16)18(13)25)31-22-21(28)20(27)19(26)17(8-23)32-22/h2-7,9,17,19-24,26-28H,8H2,1H3/t17-,19-,20+,21-,22-/m1/s1. InChi Key: WACBUPFEGWUGPB-MIUGBVLSSA-N.