Bunazosin (hydrochloride)

Bunazosin is an antagonist of the alpha1-adrenergic receptor (alpha1-AR, Kd = 0.59 nM). It reduces glutamate-induced decreases in viability in primary rat retinal cells when used at concentrations of 1 and 10 µM. Ocular instillation of bunazosin (0.01%) prevents phenylephrine- or endothelin-1-induced constriction of retinal arteries in rabbits. It also prevents reductions in refractive error and increases in axial elongation in a mouse model of lens-induced myopia. Formulations containing bunazosin have been used in the treatment of glaucoma and ocular hypertension.. SMILES: O=C(CCC)N1CCN(CCC1)C2=NC3=C(C=C(C(OC)=C3)OC)C(N)=N2.Cl. InChi Code: InChI=1S/C19H27N5O3.ClH/c1-4-6-17(25)23-7-5-8-24(10-9-23)19-21-14-12-16(27-3)15(26-2)11-13(14)18(20)22-19,/h11-12H,4-10H2,1-3H3,(H2,20,21,22),1H. InChi Key: NBGBEUITCPENLJ-UHFFFAOYSA-N