BTYNB IMP1 Inhibitor

BTYNB IMP1 inhibitor is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 µM for IMP1 binding to c-Myc mRNA). It downregulates c-Myc and beta-TrCP1 mRNA and reduces IMP1 protein levels in SK-MEL-2 and IGROV-1 cells. BTYNB IMP1 inhibits proliferation of IMP1-positive ES-2, IGROV-1, and SK-MEL-2 cells (IC50s = 2.3, 3.6, and 4.5 µM, respectively) but not IMP1-negative BG-1 and T47D-KBluc cells (IC50s = >50 µM for both). It also inhibits anchorage-independent growth of SK-MEL-2 cells when used at a concentration of 10 µM.Formal Name: 2-[[(5-bromo-2-thienyl)methylene]amino]-benzamide. CAS Number: 304456-62-0. Molecular Formula: C12H9BrN2OS. Formula Weight: 309.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=C(N)C1=CC=CC=C1/N=C/C2=CC=C(Br)S2. InChi Code: InChI=1S/C12H9BrN2OS/c13-11-6-5-8(17-11)7-15-10-4-2-1-3-9(10)12(14)16/h1-7H,(H2,14,16)/b15-7+. InChi Key: OZEADOPONHLEDS-VIZOYTHASA-N.