BRD7389

BRD7389 is an inhibitor of ribosomal S6 kinases (RSKs, IC50s = 1.5, 2.4, and 1.2 µM for RSK1, RSK2, and RSK3, respectively). Through this action, BRD7389 causes mouse alphaTC1 pancreatic alpha cells to adopt several morphological and gene expression features of beta cells, including increased insulin expression. BRD7389 also enhances glucose-stimulated insulin and glucagon secretion by pancreatic islet cells isolated from human donors with a low body mass index.Formal Name: 1-[(2-phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione. CAS Number: 376382-11-5. Molecular Formula: C24H18N2O2. Formula Weight: 366.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: :, DMF: 20 mg/mL, DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL, DMSO: 12.5 mg/mL, Ethanol: slightly soluble. lambdamax: 227, 239, 343, 444 nm. SMILES: O=C(C1=C2C(N3)=CC=C1)C4=CC=CC=C4C2=C(NCCC5=CC=CC=C5)C3=O. InChi Code: InChI=1S/C24H18N2O2/c27-23-17-10-5-4-9-16(17)21-20-18(23)11-6-12-19(20)26-24(28)22(21)25-14-13-15-7-2-1-3-8-15/h1-12,25H,13-14H2,(H,26,28). InChi Key: XASCINRGTHLHGM-UHFFFAOYSA-N.