Brazilein

Brazilein is a phytochemical that has been found in C. sappan and has diverse biological activities. It is active against E. coli, P. aeruginosa, and methicillin-susceptible S. aureus (MSSA, MICs = 32, 512, and 512 µg/ml), as well as a panel of 10 clinical isolates of methicillin-resistant S. aureus (MRSA, MIC50s = 16-32 µg/ml). Brazilein (10 µM) inhibits LPS-induced nitric oxide (NO) production in J774A.1 cells. It is cytotoxic to HepG2, Hep3B, MDA-MB-231, MCF-7, A549, and Ca9-22 cancer cells (IC50s = 3.15, 3.42, 2.36, 3.96, 9.68, and 8.63 µg/ml, respectively). Brazilein (1-10 µg/ml) also inhibits the proliferation of isolated mouse spleen lymphocytes induced by concanavalin A (Cay-14951).Formal Name: 6a,7-dihydro-3,6a,10-trihydroxy-benz[b]indeno[1,2-d]pyran-9(6H)-one. CAS Number: 600-76-0. Molecular Formula: C16H12O5. Formula Weight: 284.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 11 mg/mL, DMSO: 11 mg/mL, Ethanol: Slightly soluble, PBS (pH 7.2): 0.16 mg/mL. lambdamax: 447 nm. SMILES: O=C1C=C2C(C=C1O)=C3C4=C(OCC3(C2)O)C=C(O)C=C4. InChi Code: InChI=1S/C16H12O5/c17-9-1-2-10-14(4-9)21-7-16(20)6-8-3-12(18)13(19)5-11(8)15(10)16/h1-5,17,19-20H,6-7H2. InChi Key: MLWIYODOURBGPI-UHFFFAOYSA-N. Origin: Plant/Paubrasilia echinata.