Boc-D-FMK

Boc-D-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Also known as Boc-D(OMe)-FMK, this compound contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Boc-D-FMK blocks apoptosis stimulated by TNF-alpha in neutrophils (IC50 = 39 µM), by bile duct ligation in hepatocytes, and by TNF-alpha in renal endothelial cells. The FMK pharmacophore is known to interact with non-caspase cysteine proteases, presumably explaining why Boc-D-FMK also inhibits cathepsins H and L.Formal Name: 3S-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid, methyl ester. CAS Number: 187389-53-3. Synonyms: BAF, Boc-Asp(OMe)-FMK, Boc-D-Fluoromethyl Ketone, Boc-D(OMe)-FMK. Molecular Formula: C11H18FNO5. Formula Weight: 263.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 0.3 mg/ml. SMILES: FCC([C@@H](NC(OC(C)(C)C)=O)CC(OC)=O)=O. InChi Code: InChI=1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1. InChi Key: MXOOUCRHWJYCAL-ZETCQYMHSA-N.