BNTX (maleate)

BNTX is a delta1-opioid receptor antagonist (Ki = 0.1 nM). It is selective for the delta1-opioid receptor over the delta2-, µ-, and kappa-opioid receptors (Kis = 10.8, 13.3, and 58.6 nM, respectively). BNTX (1 and 10 µM) decreases proliferation of primary mouse splenic B cells and the production of IL-2 and IL-4 by primary mouse splenic T lymphocytes. It has antinociceptive activity in the tail-flick test in mice (ED50 = 46.4 pmol/animal) and decreases the antinociceptive activity of the delta1-opioid receptor agonist DPDPE (Cay-23184) when administered at a dose of 6.3 pmol/animal. BNTX (0.3-3 mg/kg) decreases the number of coughs induced by the terpene alkaloid capsaicin (Cay-92350) in mice. It also reduces the number of parasitized red blood cells in a mouse model of chloroquine-resistant P. chabaudi infection when administered at a dose of 10 mg/kg.Formal Name: (5alpha,7E)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-7-(phenylmethylene)-morphinan-6-one, 2Z-butenedioate. CAS Number: 864461-31-4. Synonyms: 7-Benzylidenenaltrexone. Molecular Formula: C27H27NO4 . C4H4O4. Formula Weight: 545.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: O[C@@]1(C/C2=C\C3=CC=CC=C3)[C@@]([C@@](C2=O)([H])OC4=C5O)(CC6)C4=C(C=C5)C[C@@]1([H])N6CC7CC7.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C27H27NO4.C4H4O4/c29-20-9-8-18-13-21-27(31)14-19(12-16-4-2-1-3-5-16)23(30)25-26(27,22(18)24(20)32-25)10-11-28(21)15-17-6-7-17,5-3(6)1-2-4(7)8/h1-5,8-9,12,17,21,25,29,31H,6-7,10-11,13-15H2,1-2H,(H,5,6)(H,7,8)/b19-12+,2-1-/t21-,25+,26+,27-,/m1./s1. InChi Key: GKHUUKGUNNYVGB-LQDKARLYSA-N.