BMX-IN-1

BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) that targets Cys496 in the BMX ATP binding domain. It additionally targets the related Bruton's tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent for inhibition of Blk, JAK3, EGFR, Itk, or Tec activity. BMX-IN-1 was shown to inhibit the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with a GI50 value of 25 nM. Antiproliferative activity was also observed in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines (GI50s = 2.54, 4.38, 5.37, and 2.46 µM, respectively).Formal Name: N-[2-methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide. CAS Number: 1431525-23-3. Synonyms: BMX Inhibitor 1. Molecular Formula: C29H24N4O4S. Formula Weight: 524.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/mL, DMSO: 30 mg/mL, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL. lambdamax: 260, 298 nm. SMILES: CS(NC1=CC=C(C2=CC=C(N=CC(C=C3)=C4N(C5=CC(NC(C=C)=O)=C(C)C=C5)C3=O)C4=C2)C=C1)(=O)=O. InChi Code: InChI=1S/C29H24N4O4S/c1-4-27(34)31-26-16-23(12-5-18(26)2)33-28(35)14-9-21-17-30-25-13-8-20(15-24(25)29(21)33)19-6-10-22(11-7-19)32-38(3,36)37/h4-17,32H,1H2,2-3H3,(H,31,34). InChi Key: SFMJNHNUOVADRW-UHFFFAOYSA-N.