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BMS-777607 is an inhibitor of the Met kinase family. It inhibits Ron, Met, Tyro-3, and AxI with IC50 values of 1.8, 3.9, 4.3, and 1.1 nM, respectively. At higher concentrations it is reported to inhibit Mer, FLT3, Aurora B, Lck, and VEGFR2 (IC50s = 14, 16, 78, 120, and 180 nM, respectively). In cancer cells, BMS-777607 induces polyploidy with multiple sets of chromosomes, as well as suppresses metastasis. In tumor xenograft models, BMS-777607 at 50 mg/kg/mouse inhibits the growth of tumor cells expressing Met/Ron.Formal Name: N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide. CAS Number: 1025720-94-8. Synonyms: BMS-817378. Molecular Formula: C25H19ClF2N4O4. Formula Weight: 512.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2), (1:7): 0.1 mg/ml, DMSO: 5 mg/ml. lambdamax: 204, 289 nm. SMILES: NC1=C(Cl)C(OC2=CC=C(NC(C3=C(OCC)C=CN(C4=CC=C(F)C=C4)C3=O)=O)C=C2F)=CC=N1. InChi Code: InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33). InChi Key: VNBRGSXVFBYQNN-UHFFFAOYSA-N.
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