(+)-Blebbistatin

(+)-Blebbistatin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13165-1 1 mg -

6 - 10 business days*

37.00€
Cay13165-5 5 mg -

6 - 10 business days*

154.00€
Cay13165-10 10 mg -

6 - 10 business days*

290.00€
Cay13165-25 25 mg -

6 - 10 business days*

635.00€
 
(+)-Blebbistatin is the inactive enantiomer of (-)-blebbistatin (Cay-13013), which is a selective... more
Product information "(+)-Blebbistatin"
(+)-Blebbistatin is the inactive enantiomer of (-)-blebbistatin (Cay-13013), which is a selective inhibitor of non-muscle myosin II ATPases. Prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. (R)-nitro-Blebbistatin (Cay-9001935) is a more stable form of (+)-blebbistatin. The addition of a nitro group stabilizes the molecule to circumvent its degradation by prolonged blue light exposure. (R)-nitro-Blebbistatin has the same stereochemistry as the inactive (+)-blebbistatin enantiomer. Formal Name: 1,2,3,3a-tetrahydro-3aR-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one. CAS Number: 1177356-70-5. Synonyms: (R)-Blebbistatin. Molecular Formula: C18H16N2O2. Formula Weight: 292.3. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 12.5 mg/ml. lambdamax: 236, 270, 298, 418 nm. SMILES: Cc1ccc2N=C3N(CC[C@@]3(O)C(=O)c2c1)c1ccccc1. InChi Code: InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m0/s1. InChi Key: LZAXPYOBKSJSEX-SFHVURJKSA-N.
Keywords: (R)-Blebbistatin, 1,2,3,3a-tetrahydro-3aR-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
Supplier: Cayman Chemical
Supplier-Nr: 13165

Properties

Application: Non-muscle myosin II ATPase inhibitor
MW: 292.3 D
Formula: C18H16N2O2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 1177356-70-5| Find alternatives
KEGG ID : K10352 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H312, H315, H317, H319, H332, H335
P Phrases: P261, P264, P270, P271, P272, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P333+313, P337+313, P361+364, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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