BIX

BIX is an inducer of the chaperone protein glucose-regulated protein 78 kDa (GRP78), also known as heat shock 70 kDa protein 5 (HspA5) and immunoglobulin heavy chain-binding protein (BiP). It induces expression of the gene encoding GRP78, but not those encoding calreticulin, CHOP, EDEM, p58IPK, or ASNA, in SK-N-SH neuroblastoma cells when used at a concentration of 50 µM. BIX (5 µM) reduces endoplasmic reticulum (ER) stress-induced apoptosis in SK-N-SH cells. In vivo, BIX (20 µg/2 µl, i.c.v.) reduces infarct volume and brain swelling in a mouse model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO). It protects against carotid artery occlusion-induced neuronal apoptosis in gerbil hippocampus. BIX also increases renal GRP78 protein levels and attenuates ischemia and reperfusion-induced renal injury in mice.Formal Name: 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid. CAS Number: 101714-41-4. Synonyms: BiP Inducer X. Molecular Formula: C9H7NO3S. Formula Weight: 209.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 235, 283, 315 nm. SMILES: N#CSCC(C1=CC=C(C(O)=C1)O)=O. InChi Code: InChI=1S/C9H7NO3S/c10-5-14-4-9(13)6-1-2-7(11)8(12)3-6/h1-3,11-12H,4H2. InChi Key: SVFLBLCWKKQKDW-UHFFFAOYSA-N.