Bisindolylmaleimide IV

Bisindolylmaleimide IV (BIM IV) is a cell permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 µM. BIM IV was designed to be more discriminative than its parent compound, the non-selective PKC inhibitor, staurosporine (Cay-81590). However, BIM IV also inhibits protein kinase A with IC50 values ranging from 2 to 11.8 µM.Formal Name: 3,4-di-1H-indol-3-yl-1H-pyrrole-2,5-dione. CAS Number: 119139-23-0. Synonyms: Arcyriarubin A, BIM IV. Molecular Formula: C20H13N3O2. Formula Weight: 327.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 276, 373, 461 nm. SMILES: O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12. InChi Code: InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25). InChi Key: DQYBRTASHMYDJG-UHFFFAOYSA-N.