Bikaverin

Bikaverin is a fungal metabolite originally isolated from F. oxysporum f. sp. lycopersici that has diverse biological activities. It is active against L. braziliensis when used at a concentration of 0.15 µg/ml and against B. xylophilus at a concentration of 100 µg/ml. It inhibits proliferation of NCI-H460, MIA PaCa-2, MCF-7, and SF-268 cells (IC50s = 0.43, 0.26, 0.42, and 0.38 µM, respectively). Bikaverin inhibits the growth of certain plant pathogenic fungi, including R. solani, P. capsici, P. infestans, and M. grisea (IC50s = P. infestans and P. recondita, respectively, when applied at a concentration of 300 µg/ml.Formal Name: 6,11-dihydroxy-3,8-dimethoxy-1-methyl-10H-benzo[b]xanthene-7,10,12-trione. CAS Number: 33390-21-5. Synonyms: Lycopersin, NSC 215139. Molecular Formula: C20H14O8. Formula Weight: 382.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(C=C1OC)C2=C(C(O)=C(OC(C=C(OC)C=C3C)=C3C4=O)C4=C2O)C1=O. InChi Code: InChI=1S/C20H14O8/c1-7-4-8(26-2)5-10-12(7)17(23)15-18(24)13-9(21)6-11(27-3)16(22)14(13)19(25)20(15)28-10/h4-6,24-25H,1-3H3. InChi Key: ZOQMSOSJEWBMHP-UHFFFAOYSA-N. Origin: Fungus/Fusarium sp..