Bicyclol

Bicyclol is a hepatoprotective agent. It has antiviral activity against hepatitis B (HBV), reducing viral DNA and the secretion of the HBV antigens HBsAg and HBeAg by 59 and 35%, respectively, in infected 2.2.15 HepG2 cells. In vivo, bicyclol reduces duck HBV (DHBV) DNA in DHBV-infected ducks at doses >0.4 g/kg. It also reduces the expression of TNF-alpha and the accumulation of lymphocytes in the liver in a mouse model of liver injury induced by concanavalin A (Cay-14951). Oral administration of bicyclol prior to injection of diethylnitrosamine (DEN) and phenobarbital (PB, Cay-9001494, Cay-20987) prevents formation of DEN/PB-induced hepatocellular carcinomas. It also reduces liver fibrosis in a rat model of bile duct ligation-induced hepatic fibrosis.Formal Name: 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bi-1,3-benzodioxole]-5-carboxylic acid, methyl ester. CAS Number: 118159-48-1. Molecular Formula: C19H18O9. Formula Weight: 390.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml. lambdamax: 211, 228, 273 nm. SMILES: O=C(OC)C1=CC(OC)=C(OCO2)C2=C1C3=C(CO)C=C(OC)C4=C3OCO4. InChi Code: InChI=1S/C19H18O9/c1-22-11-4-9(6-20)13(17-15(11)25-7-27-17)14-10(19(21)24-3)5-12(23-2)16-18(14)28-8-26-16/h4-5,20H,6-8H2,1-3H3. InChi Key: KXMTXZACPVCDMH-UHFFFAOYSA-N.