beta-Pseudouridine

beta-Pseudouridine is the C-5 glycoside isomer of the nucleoside uridine (Cay-20300). It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. beta-pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes. In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner.Formal Name: 5-beta-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione. CAS Number: 1445-07-4. Synonyms: NSC 162405, 5-Ribosyluracil. Molecular Formula: C9H12N2O6. Formula Weight: 244.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 208, 265 nm. SMILES: O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C(C(N2)=O)=CNC2=O. InChi Code: InChI=1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1. InChi Key: PTJWIQPHWPFNBW-GBNDHIKLSA-N.