Benzomalvin A

Benzomalvin A is a fungal metabolite produced by Penicillium. It inhibits yeast alpha-glucosidase in vitro (IC50 = 383.2 µM). In vivo, benzomalvin A (3.1-31.6 mg/kg) decreases plasma glucose levels in mice following administration of sucrose. It also decreases the plasma glucose postprandial peak in nicotinamide-streptozotocin-induced hyperglycemic mice when administered at a dose of 10 mg/kg. Benzomalvin A also acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P (Cay-24035) to guinea pig, rat, and human NK1 (Kis = 12, 42, and 43 µM, respectively).Formal Name: (6S,7S)-6,7-dihydro-6-methyl-7-(phenylmethyl)-quinazolino[3,2-a][1,4]benzodiazepine-5,13-dione. CAS Number: 157047-96-6. Synonyms: (-)-Benzomalvin A. Molecular Formula: C24H19N3O2. Formula Weight: 381.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: O=C1N2C(C(CC3=CC=CC=C3)N(C)C(C4=C2C=CC=C4)=O)=NC5=CC=CC=C51. InChi Code: InChI=1S/C24H19N3O2/c1-26-21(15-16-9-3-2-4-10-16)22-25-19-13-7-5-11-17(19)24(29)27(22)20-14-8-6-12-18(20)23(26)28/h2-14,21H,15H2,1H3. InChi Key: YYWUABJYAOCACI-UHFFFAOYSA-N.