BC-1215

BC-1215 is an inhibitor of F-box protein 3 (FBXO3, IC50 = 0.9 µg/mL for Il-1beta release). It decreases FBXO3 interaction with F-box/LRR-repeat protein 2 (FBXL2) in a dose-dependent manner and prevents FBXO3-dependent ubiquitination of FBXL2. It also lowers expression of Tnf receptor-associated factors (TRAFs) 1-6 without affecting TRAF1-6 mRNA levels in resting and LPS-stimulated peripheral blood mononuclear cells (PBMCs). BC-1215 (100 µg, i.p., per animal) reduces plasma levels of the inflammatory cytokines Il-6, Tnf, and Il-1beta and decreases peritoneal bacteria counts in a mouse model of cecal ligation and puncture-induced sepsis. It also reduces inflammation in mouse models of DSS-induced colitis, paw edema, and ear edema.Formal Name: N1,N2-bis[[4-(2-pyridinyl)phenyl]methyl]-1,2-ethanediamine. CAS Number: 1507370-20-8. Molecular Formula: C26H26N4. Formula Weight: 394.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/ml. lambdamax: 250, 280 nm. SMILES: C1(C2=CC=C(CNCCNCC3=CC=C(C4=CC=CC=N4)C=C3)C=C2)=CC=CC=N1. InChi Code: InChI=1S/C26H26N4/c1-3-15-29-25(5-1)23-11-7-21(8-12-23)19-27-17-18-28-20-22-9-13-24(14-10-22)26-6-2-4-16-30-26/h1-16,27-28H,17-20H2. InChi Key: IXEPQJQQSLMESJ-UHFFFAOYSA-N.