BBT594

BBT594 is an inhibitor of Bcr-AblT315I (IC50 = 44 nM), a form of the Bcr-Abl fusion protein containing a tyrosine-to-isoleucine substitution at position 315. It decreases proliferation in mouse Ba/F3 hematopoietic cells expressing Bcr-AblT315I (GI50 = 117 nM). BBT594 (1 or 5 µM) also inhibits phosphorylation of Jak2 and Stat5 in Ba/F3 cells.Formal Name: 5-[[6-(acetylamino)-4-pyrimidinyl]oxy]-2,3-dihydro-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-1H-indole-1-carboxamide. CAS Number: 882405-89-2. Synonyms: NVP-BBT594. Molecular Formula: C28H30F3N7O3. Formula Weight: 569.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: O=C(C)NC1=CC(OC2=CC=C3C(CCN3C(NC(C=C4C(F)(F)F)=CC=C4CN5CCN(CC5)C)=O)=C2)=NC=N1. InChi Code: InChI=1S/C28H30F3N7O3/c1-18(39)34-25-15-26(33-17-32-25)41-22-5-6-24-19(13-22)7-8-38(24)27(40)35-21-4-3-20(23(14-21)28(29,30)31)16-37-11-9-36(2)10-12-37/h3-6,13-15,17H,7-12,16H2,1-2H3,(H,35,40)(H,32,33,34,39). InChi Key: VQLNKQZLPGLOSI-UHFFFAOYSA-N.