BAY 60-7550

BAY 60-7550
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10011135-1 1 mg -

6 - 10 business days*

94.00€
Cay10011135-5 5 mg -

6 - 10 business days*

249.00€
Cay10011135-10 10 mg -

6 - 10 business days*

450.00€
 
The second messengers cAMP and cGMP are important mediators of signal transduction and hence a... more
Product information "BAY 60-7550"
The second messengers cAMP and cGMP are important mediators of signal transduction and hence a wide range of cellular processes including vasodilation and synaptic plasticity. Type 2 cyclic nucleotide phosphodiesterases (PDE2) isoforms inactivate cAMP and cGMP by hydrolyzing the phosphodiester bond. BAY 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human). It is 50-fold more selective for PDE2 compared to PDE1 and greater than 100-fold selective compared to PDE5 PDE3B, PDE4B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A. At 3 mg/kg BAY 60-7550 antagonizes oxidative stress-induced anxiety-like behavioral effects in mice by increasing cGMP signaling. At 1 mg/kg BAY 60-7550 improves the performance of rats in an object location task, enhancing cAMP/cGMP-mediated object and spatial memory consolidation. Formal Name: 2-[(3,4-dimethoxyphenyl)methyl]-7-[(1R)-1-hydroxyethyl]-4-phenylbutyl]-5-methyl-imidazo[5,1-f][1,2,4]triazin-4(1H)-one. CAS Number: 439083-90-6. Molecular Formula: C27H32N4O4. Formula Weight: 476.6. Purity: >95%. Formulation: A crystalline solid. Solubility: Acetone: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. SMILES: COc1cc(ccc1OC)Cc1[nH]c(=O)c2c(C)nc([C@@H](CCCc3ccccc3)[C@@H](C)O)n2n1. InChi Code: InChI=1S/C27H32N4O4/c1-17-25-27(33)29-24(16-20-13-14-22(34-3)23(15-20)35-4)30-31(25)26(28-17)21(18(2)32)12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,18,21,32H,8,11-12,16H2,1-4H3,(H,29,30,33)/t18-,21+/m1/s1. InChi Key: MYTWFJKBZGMYCS-NQIIRXRSSA-N.
Keywords: 2-[(3,4-dimethoxyphenyl)methyl]-7-[(1R)-1-hydroxyethyl]-4-phenylbutyl]-5-methyl-imidazo[5,1-f][1,2,4]triazin-4(1H)-one
Supplier: Cayman Chemical
Supplier-Nr: 10011135

Properties

Application: PDE2 inhibitor
MW: 476.6 D
Formula: C27H32N4O4
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 439083-90-6| Find alternatives
KEGG ID : K13294 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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