BAY 12-17389

BAY 12-17389 is an inhibitor of monopolar spindle 1 (Mps1, IC50 = 0.63 nM). It is selective for Mps1 over a panel of kinases at 10 nM. BAY 12-17389 promotes cell-cycle progression into mitosis in metaphase-arrested HeLa cells (IC50 = 11 nM). BAY 12-17389 (1.5 mg/kg) enhances paclitaxel-induced inhibition of tumor growth in a SUM149 triple-negative breast cancer (TNBC) mouse xenograft model.Formal Name: N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methyl-benzamide. CAS Number: 1554458-53-5. Molecular Formula: C27H24F5N5O3. Formula Weight: 561.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 15 mg/ml. lambdamax: 271, 304 nm. SMILES: COC1=C(F)C(F)=C(OC2=NN3C(C(NCCC(F)(F)F)=C2)=NC=C3C4=CC(C)=C(C(NC5CC5)=O)C=C4)C=C1. InChi Code: InChI=1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,11-13,16,33H,4-5,9-10H2,1-2H3,(H,35,38). InChi Key: WNEILUNVMHVMPH-UHFFFAOYSA-N.