BAY 11-7082

BAY 11-7082
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010266-5 5 mg -

6 - 10 business days*

49.00€
Cay10010266-10 10 mg -

6 - 10 business days*

93.00€
Cay10010266-25 25 mg -

6 - 10 business days*

220.00€
Cay10010266-50 50 mg -

6 - 10 business days*

390.00€
 
The transcription factor NF-kappaB plays a key role in regulating over 150 target genes including... more
Product information "BAY 11-7082"
The transcription factor NF-kappaB plays a key role in regulating over 150 target genes including the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules. In the cytoplasm, inactive NF-kappaB complexes are bound to an inhibitor IkappaB. However in response to certain stimuli, IkappaB is phosphorylated, ubiquitinated, and degraded, enabling the translocation of NF-kappaB to the nucleus. BAY 11-7082 selectively and irreversibly inhibits NF-kappaB activation by blocking TNF-alpha-induced phosphorylation of IkappaB-alpha without affecting constitutive IkappaB-alpha phosphorylation. This compound inhibits the TNF-alpha-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC50 values of 5-10 µM. Formal Name: 3-[(4-methylphenyl)sulfonyl]-(2E)-propenenitrile. CAS Number: 19542-67-7. Molecular Formula: C10H9NO2S. Formula Weight: 207.3. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 25 mg/ml, Ethanol: 0.20 mg/ml. lambdamax: 251 nm. SMILES: N#C/C=C/S(=O)(=O)c1ccc(C)cc1. InChi Code: InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+. InChi Key: DOEWDSDBFRHVAP-KRXBUXKQSA-N. Origin: Synthetic.
Keywords: 3-[(4-methylphenyl)sulfonyl]-(2E)-propenenitrile
Supplier: Cayman Chemical
Supplier-Nr: 10010266

Properties

Application: NF-kappaB activation inhibitor
MW: 207.3 D
Formula: C10H9NO2S
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 19542-67-7| Find alternatives
KEGG ID : K04734 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319
P Phrases: P264, P270, P280, P301+310, P302+352, P305+351+338, P321, P330, P332+313, P337+313, P362+364, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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