Bambuterol (hydrochloride)

Bambuterol is a prodrug form of the beta-adrenergic receptor (beta-AR) agonist terbutaline (Cay-29337). It is also an inhibitor of butyrylcholinesterase (BChE, IC50 = 3.9 nM for the human enzyme), the enzyme that metabolizes bambuterol into terbutaline, and this inhibition increases the duration of action of terbutaline. Bambuterol (1 and 2 mg/kg) increases the latency to histamine-induced collapse in guinea pigs. It completely inhibits ovalbumin-induced decreases in dynamic compliance and increases in pulmonary resistance in ovalbumin-sensitized guinea pigs when administered at a dose of 10 mg/kg. Formulations containing bambuterol have been used in the treatment of asthma.Formal Name: N,N-dimethyl-carbamic acid-3-[[(dimethylamino)carbonyl]oxy]-5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]phenyl ester, monohydrochloride. CAS Number: 81732-46-9. Synonyms: KWD 2183. Molecular Formula: C18H29N3O5 . HCl. Formula Weight: 403.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: OC(CNC(C)(C)C)C1=CC(OC(N(C)C)=O)=CC(OC(N(C)C)=O)=C1.Cl. InChi Code: InChI=1S/C18H29N3O5.ClH/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7,/h8-10,15,19,22H,11H2,1-7H3,1H. InChi Key: LBARATORRVNNQM-UHFFFAOYSA-N.