Azimilide (hydrochloride)

Azimilide is a class III antiarrhythmic agent. It blocks rapidly activating delayed rectifier (IKr) and slowly activating delayed rectifier (IKs) potassium currents in isolated guinea pig ventricular myocytes (IC50s = 0.3 and 3 µM, respectively). Azimilide (0.1-10 µM) prolongs action potential duration (APD) in isolated calf Purkinje fibers and ventricular trabeculae in a concentration-dependent manner. It increases the effective refractory period (ERP) in isolated perfused guinea pig hearts and ferret papillary muscles. Azimilide (0.3-30 mg/kg) increases ERP and the absolute refractory period and decreases heart rate in dogs. It reduces mean arrhythmia score in a rat model of coronary artery ligation and reperfusion-induced severe ventricular arrhythmia. Azimilide (10-30 mg/kg) also prevents sustained and non-sustained ventricular tachyarrhythmias in dogs.Formal Name: 1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione, dihydrochloride. CAS Number: 149888-94-8. Synonyms: NE 10064. Molecular Formula: C23H28ClN5O3 . 2HCl. Formula Weight: 530.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 233, 257, 343 nm. SMILES: ClC1=CC=C(C2=CC=C(/C=N/N3C(N(CCCCN4CCN(C)CC4)C(C3)=O)=O)O2)C=C1.Cl.Cl. InChi Code: InChI=1S/C23H28ClN5O3.2ClH/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18,,/h4-9,16H,2-3,10-15,17H2,1H3,2*1H/b25-16+,,. InChi Key: HHPSICLSNHCSNZ-BYEGLACWSA-N.