AZD 4320

An inhibitor of the Bcl-2-Bim and Bcl-xL-Bim protein-protein interactions (IC50s = 3.9 and 4.5 nM, respectively, in fluorescence polarization assays), induces apoptosis in MLL-AF9,NrasG12D mouse AML cells overexpressing human Bcl-2 or Bcl-xL but not Mcl-1, Bfl-1, or Bcl-W at 1 µM, induces apoptosis in wild-type but not Bax/Bak-/- SW48 cells, reduces tumor volume but induces transient thrombocytopenia in an RS4,11 ALL mouse xenograft model at 20 mg/kg. Formulation: A solid. InChI: InChI=1S/C45H48ClF3N4O7S3/c1-52(27-28-54)24-23-35(30-61-37-7-3-2-4-8-37)50-41-20-19-38(29-42(41)62(57,58)45(47,48)49)63(59,60)51-44(56)33-13-17-36(18-14-33)53-25-21-32(22-26-53)43(55)40-10-6-5-9-39(40)31-11-15-34(46)16-12-31/h2-20,29,32,35,43,50,54-55H,21-28,30H2,1H3,(H,51,56)/t35-,43-/m1/s1. InChIKey: UNEJSHNDABUZNY-UJNHCCGESA-N. SMILES: OCCN(C)CC[C@@H](NC1=C(S(=O)(C(F)(F)F)=O)C=C(S(NC(C2=CC=C(N3CCC(CC3)[C@H](C4=C(C5=CC=C(C=C5)Cl)C=CC=C4)O)C=C2)=O)(=O)=O)C=C1)CSC6=CC=CC=C6