AZ1 USP25/28 Inhibitor

AZ1 USP25/28 Inhibitor is a dual inhibitor of ubiquitin-specific protease 25 (USP25) and USP28 (IC50s = 0.7 and 0.6 µM, respectively). It is selective for USP25 and USP28 over USP2a (IC50 = >100 µM), a panel of 22 other deubiquitinases at 10 µM, and a panel of eight caspases and cathepsins at 30 µM. AZ1 USP25/28 Inhibitor induces degradation of c-Myc in HCT116 cells in a concentration-dependent manner, an effect that can be reversed by the proteasome inhibitor MG132. It decreases the viability of several cancer cell lines (EC50s = 9.8-33.5 µM).Formal Name: 2-[[[5-bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]-ethanol. CAS Number: 2165322-94-9. Synonyms: AZ1 Ubiquitin-specific Protease 25/28 Inhibitor. Molecular Formula: C17H16BrF4NO2. Formula Weight: 422.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: FC1=CC=C(COC2=CC=C(C=C2CNCCO)Br)C=C1C(F)(F)F. InChi Code: InChI=1S/C17H16BrF4NO2/c18-13-2-4-16(12(8-13)9-23-5-6-24)25-10-11-1-3-15(19)14(7-11)17(20,21)22/h1-4,7-8,23-24H,5-6,9-10H2. InChi Key: ITHSFXDGKQYOED-UHFFFAOYSA-N.