Aurora Kinase Inhibitor III

Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase (IC50 = 42 nM). It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively).Formal Name: N-[3-[[4-[[3-(trifluoromethyl)phenyl]amino]-2-pyrimidinyl]amino]phenyl]-cyclopropanecarboxamide. CAS Number: 879127-16-9. Molecular Formula: C21H18F3N5O. Formula Weight: 413.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 50 mg/ml, Ethanol: 20 mg/ml. SMILES: O=C(C1CC1)NC2=CC=CC(NC3=NC=CC(NC4=CC=CC(C(F)(F)F)=C4)=N3)=C2. InChi Code: InChI=1S/C21H18F3N5O/c22-21(23,24)14-3-1-4-15(11-14)26-18-9-10-25-20(29-18)28-17-6-2-5-16(12-17)27-19(30)13-7-8-13/h1-6,9-13H,7-8H2,(H,27,30)(H2,25,26,28,29). InChi Key: RDTDWGQDFJPTPD-UHFFFAOYSA-N.