Aspulvinone O

Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals in a cell-free assay (IC50 = 11.6 µM). Aspulvinone O inhibits aspartate transaminase 1 (GOT1, Kd = 3.32 µM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 µM). It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) reduces tumor growth in an SW1990 mouse xenograft model.Formal Name: 3-[2,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-4-hydroxy-5-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methylene]-2(5H)-furanone. CAS Number: 914071-54-8. Molecular Formula: C27H28O6. Formula Weight: 448.5. Purity: >85%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: OC1=C(C(C(O/2)=O)=C(O)C2=C\C3=CC=C(O)C(C/C=C(C)\C)=C3)C=C(C/C=C(C)/C)C(O)=C1. InChi Code: InChI=1S/C27H28O6/c1-15(2)5-8-18-11-17(7-10-21(18)28)12-24-26(31)25(27(32)33-24)20-13-19(9-6-16(3)4)22(29)14-23(20)30/h5-7,10-14,28-31H,8-9H2,1-4H3/b24-12-. InChi Key: IAHWCROWFXOMDG-MSXFZWOLSA-N. Origin: Fungus/Aspergillus sp..