Aspergillin PZ

Description: Aspergillin PZ is a fungal metabolite originally isolated from A. awamori. It induces morphological deformation of P. oryzae conidia when used at a concentration of 89 nM. Aspergillin PZ is active against S. epidermidis (MIC = 20 µM) but not S. aureus, E. coli, or B. cereus (MICs = >20 µM). It is cytotoxic to HL-60 promyelocytic leukemia cells (IC50 = 56.61 µM) but not THP-1 acute monocytic leukemia or PC3 prostate cancer cells (IC50s = >80 µM). Target: Others. Smiles: [H][C@]12CC(=O)[C@@]34C(=O)N[C@@H](CC(C)C)[C@]3([H])[C@H](C)C(C)=C[C@]4([H])[C@@]1([H])[C@]1(C)CC[C@@H](O)[C@@]2([H])O1 , c:20,TLB:21:23:33:27.28.29,2:1:33:27.28.29,THB:30:29:23.1:33,