Asialo Ganglioside GM1

Asialo ganglioside GM1 is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 (Cay-19579) by neuraminidase. Asialo ganglioside GM1 is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-asialo ganglioside GM1 antibody. The percentage of asialo ganglioside GM1-positive natural killer (NK) and CD8+ T cells in lung is increased in a mouse model of respiratory syncytial virus (RSV) infection compared with healthy animals. Depletion of asialo ganglioside GM1-positive NK and T cells reduces IFN-gamma levels in the lung, reduces weight loss, and increases lung viral load in RSV-infected mice. This product contains ganglioside GM1 molecular species with primarily C18:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1064]CAS Number: 71012-19-6. Synonyms: ASGM1, Asialo GM1, Gangliotetraosylceramide. Molecular Formula: C62H114N2O23 (for stearoyl). Purity: >98%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Chloroform:Methanol (2:1): Soluble. SMILES: [H][C@](CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)O)O)CO)O)O)CO)([C@](O)(/C=C/CCCCCCCCCCCCC)[H])NC(CCCCCCCCCCCCCCCCC)=O. InChi Code: InChI=1S/C62H114N2O23/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-46(71)64-40(41(70)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)38-80-60-54(78)51(75)57(44(36-67)83-60)86-62-55(79)52(76)56(45(37-68)84-62)85-59-47(63-39(3)69)58(49(73)43(35-66)81-59)87. InChi Key: VELGMVLNORPMAO-HMWOVMCASA-N.