Aromadendrin

Aromadendrin is a flavone that has been found in J. chinensis and has diverse biological activities. It scavenges DPPH (Cay-14805) radicals (IC50 = 2.21 µM) and inhibits acetylcholinesterase (AChE, IC50 = 35.43 µM), but not butyrylcholinesterase (BChE) and beta-secretase 1 (BACE1, IC50s = >200 µM), in cell-free assays. Aromadendrin inhibits the growth of BT474 breast, ChaGo-K-1 lung, HepG2 liver, KATO III gastric, and SW620 colon cancer cells (IC50s = 11.66, 12.32, 13.67, 39.79, and 41.11 µM, respectively). It prevents cytokine production in anti-CD3 and anti-CD28-stimulated T cells in a concentration-dependent manner. Aromadendrin reduces pancreatic damage in a mouse model of caerulin and LPS-induced severe acute pancreatitis in a dose-dependent manner.Formal Name: (2R,3R)-2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 480-20-6. Synonyms: (+)-Aromadendrin, (+)-Dihydrokaempferol, Dihydrokaempferol, trans-Dihydrokaempferol. Molecular Formula: C15H12O6. Formula Weight: 288.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mM. lambdamax: 214, 292 nm. SMILES: OC1=C2C(O[C@H]([C@@H](C2=O)O)C3=CC=C(O)C=C3)=CC(O)=C1. InChi Code: InChI=1S/C15H12O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,14-18,20H/t14-,15+/m1/s1. InChi Key: PADQINQHPQKXNL-CABCVRRESA-N. Origin: Plant/Kaempferia galanga.