Ara-G

Description: Ara-G is a deoxyguanosine (GdR) analog and a nucleoside analogue that is rapidly converted by cells of the T lymphoid lineage to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and selective in vitro toxicity to T lymphoblastoid cell lines as well as to freshly isolated leukemia cells from patients with T cell acute lymphoblastic leukemia (ALL). Target: Nucleoside Antimetabolite/Analog. Smiles: Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O. References: Kurtzberg J. Guanine arabinoside as a bone marrow-purging agent. Ann N Y Acad Sci. 1993 Jun 23,685:225-36.