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Description: APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with inhibition constants (Kis) of 1.08 µM, 0.57 µM, and 0.63 µM for Nox1, Nox2, and Nox4, respectively, and it effectively prevents kidney injury. Target: NADPH-oxidase, NADPH. Smiles: CCCc1c(O)n(nc1-c1ccccc1)-c1ccccn1. References: Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16,8(43):74217-74232.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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