Anthralin

Anthralin is an anthrone inhibitor of keratinocyte proliferation and a modulator of differentiation. It increases apoptosis and inhibits proliferation of normal human keratinocytes (NHKs) when used at a concentration of 2.5 µM. It also decreases the mitochondrial membrane potential, increases cytochrome c release, and induces perinuclear mitochondrial clustering in NHKs when used at a concentration of 5 µM. Anthralin (0.25 µM) decreases the expression of beta-defensin-2 (Cay-24577) and S100 calcium-binding protein A9 (S100A9) and increases the expression of IL-6 and IL-8 in IL-17A- and IL-22-stimulated NHKs. It also inhibits leukotriene B4 (LTB4, Cay-20110) production, stimulated by the calcium ionophore A23187 (Cay-11016), from human neutrophils (IC50 = 7 µM). Topical anthralin (0.1%) induces hair regrowth in a Dundee experimental bald rat (DEBR) model of alopecia areata.Formal Name: 1,8-dihydroxy-9(10H)-anthracenone. CAS Number: 1143-38-0. Synonyms: 1,8,9-Anthracenetriol, Dithranol, NSC 43970, NSC 629313. Molecular Formula: C14H10O3. Formula Weight: 226.2. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10mg/mL, DMF:PBS (pH 7.2) (1:3): 0.25mg/mL, DMSO: 5mg/mL. lambdamax: 257, 289, 356 nm. SMILES: OC1=C2C(CC(C=CC=C3O)=C3C2=O)=CC=C1. InChi Code: InChI=1S/C14H10O3/c15-10-5-1-3-8-7-9-4-2-6-11(16)13(9)14(17)12(8)10/h1-6,15-16H,7H2. InChi Key: NUZWLKWWNNJHPT-UHFFFAOYSA-N.