Amiselimod (hydrochloride)

Amiselimod is a prodrug form of the sphingosine-1-phosphate receptor 1 (S1P1) antagonist amiselimod phosphate (amiselimod-P). In vivo, amiselimod (0.3 mg/kg per day) inhibits the development of chronic colitis induced by adoptive transfer of CD4+CD45RBhigh T cells in mice.Formal Name: 2-amino-2-[2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl]-1,3-propanediol, monohydrochloride. CAS Number: 942398-84-7. Synonyms: MT-1303. Molecular Formula: C19H30F3NO3 . HCl. Formula Weight: 413.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 20 mg/nl, Ethanol: 15 mg/ml. lambdamax: 225, 283 nm. SMILES: CCCCCCCOC1=C(C(F)(F)F)C=C(CCC(CO)(N)CO)C=C1.Cl. InChi Code: InChI=1S/C19H30F3NO3.ClH/c1-2-3-4-5-6-11-26-17-8-7-15(12-16(17)19(20,21)22)9-10-18(23,13-24)14-25,/h7-8,12,24-25H,2-6,9-11,13-14,23H2,1H3,1H. InChi Key: GEDVJGOVRLHFQG-UHFFFAOYSA-N.