Aminoethyl-SS-Propionic Acid

Aminoethyl-SS-propionic acid is a cleavable disulfide linker. It has been used in the synthesis of antibody-drug conjugates (ADCs) containing the antibody trastuzumab and a membrane-impermeable cytotoxin, which inhibits HER2 dimerization and induces cytotoxicity in HER2-positive breast cancer cells, respectively.Formal Name: 3-[(2-aminoethyl)dithio]-propanoic acid. CAS Number: 15579-00-7. Molecular Formula: C5H11NO2S2. Formula Weight: 181.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 16 mg/ml, DMSO: 11 mg/ml, Ethanol: Slightly soluble, PBS (pH 7.2): 5 mg/ml. SMILES: O=C(CCSSCCN)O. InChi Code: InChI=1S/C5H11NO2S2/c6-2-4-10-9-3-1-5(7)8/h1-4,6H2,(H,7,8). InChi Key: HMMFDEBVQNRZLJ-UHFFFAOYSA-N.