Amidepsine A

Diacylglycerol acyltransferases (DGATs) catalyze the final step in triglyceride synthesis. DGAT-1 deficient mice demonstrate a phenotype that is protective against the development of diet-induced obesity or insulin resistance, implicating the actions of this enzyme in the development of such metabolic disorders. Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits DGAT activity (IC50 = 10.2 µM in rat liver microsomes). It inhibits triacylglycerol formation in Raji cells with an IC50 value of 15.5 µM.Formal Name: 2,4-dimethoxy-6-methyl-benzoic acid, 4-[[4-[[(1-carboxyethyl)amino]carbonyl]-3-hydroxy-5-methylphenoxy]carbonyl]-3-hydroxy-5-methylphenyl ester. CAS Number: 169181-28-6. Synonyms: FO-2942A. Molecular Formula: C29H29NO11. Formula Weight: 567.5. Purity: >95%. Formulation: (Request formulation change), A powder. Solubility: Methanol: Soluble. SMILES: OC1=C(C(NC(C)C(O)=O)=O)C(C)=CC(OC(C2=C(O)C=C(OC(C3=C(C)C=C(OC)C=C3OC)=O)C=C2C)=O)=C1. InChi Code: InChI=1S/C29H29NO11/c1-13-8-18(10-20(31)23(13)26(33)30-16(4)27(34)35)40-28(36)24-14(2)9-19(11-21(24)32)41-29(37)25-15(3)7-17(38-5)12-22(25)39-6/h7-12,16,31-32H,1-6H3,(H,30,33)(H,34,35). InChi Key: XQGKRCPZJSNFEL-UHFFFAOYSA-N. Origin: Fungus/Humicola sp. FO-2942.