Amarogentin

Amarogentin is a secoiridoid glycoside that has been found in Swertia and has diverse biological activities, including anticancer, antidiabetic, and anti-leishmanial properties. It inhibits the growth of SNU-16 human gastric cancer cells (IC50 = 12.4 µM after 48 hours) and increases apoptosis when used at a concentration of 50 µM. Amarogentin (10-50 mg/kg, s.c.) dose-dependently reduces tumor growth in a SNU-16 nude mouse xenograft model. It reduces plasma glucose levels in a rat model of diabetes induced by streptozotocin (STZ, Cay-13104) in a dose-dependent manner and reverses the STZ-induced increase in soleus muscle levels of glucose transporter 4 (Glut4) when administered at a dose of 0.5 mg/kg. Amarogentin reduces parasite burden in the spleen of hamsters infected with L. donovani in a dose-dependent manner.Formal Name: 5-ethenyl-4,4aS,5R,6S-tetrahydro-6-[[2-O-[(3,3',5-trihydroxy[1,1'-biphenyl]-2-yl)carbonyl]-beta-D-glucopyranosyl]oxy]-1H,3H-pyrano[3,4-c]pyran-1-one. CAS Number: 21018-84-8. Molecular Formula: C29H30O13. Formula Weight: 586.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 2 mg/ml, PBS (pH 7.2): 0.1 mg/ml. lambdamax: 218, 228, 264, 302 nm. SMILES: O=C1OCC[C@]2([H])C1=CO[C@@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3OC(C4=C(C5=CC=CC(O)=C5)C=C(O)C=C4O)=O)[C@@H]2C=C. InChi Code: InChI=1S/C29H30O13/c1-2-16-17-6-7-38-26(36)19(17)12-39-28(16)42-29-25(24(35)23(34)21(11-30)40-29)41-27(37)22-18(9-15(32)10-20(22)33)13-4-3-5-14(31)8-13/h2-5,8-10,12,16-17,21,23-25,28-35H,1,6-7,11H2/t16-,17+,21-,23-,24+,25-,28+,29+/m1/s1. InChi Key: DBOVHQOUSDWAPQ-WTONXPSSSA-N.