AM-2394

Item number	Size	Datasheet	Manual	SDS	Delivery time	Price
TGM-T3312-2mg	2 mg	-	-	-	5 - 10 business days*	30.00€
TGM-T3312-5mg	5 mg				5 - 10 business days*	44.00€
TGM-T3312-1mL	1 ml				5 - 10 business days*	48.00€
TGM-T3312-10mg	10 mg				5 - 10 business days*	65.00€
TGM-T3312-25mg	25 mg				5 - 10 business days*	111.00€
TGM-T3312-50mg	50 mg				5 - 10 business days*	181.00€
TGM-T3312-100mg	100 mg				5 - 10 business days*	280.00€
TGM-T3312-200mg	200 mg	-	-	-	5 - 10 business days*	434.00€

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Description: AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which... more

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Product information "AM-2394"

Description: AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. Target: Glucokinase. Smiles: CNC(=O)Nc1cc(Oc2cncc(C)c2)c(cn1)-c1ccc(OCC(C)(C)O)nc1. References: Dransfield PJ, et al. Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394. ACS Med Chem Lett. 2016 May 23,7(7):714-8.

Keywords:	AM2394
Supplier:	TargetMol
Supplier-Nr:	T3312

Properties

MW:	423.46 D
Formula:	C22H25N5O4

Database Information

Handling & Safety

Storage:	+4°C
Shipping:	+20°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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