Altretamine

Altretamine is an antineoplastic agent with antiproliferative activity. It induces cytotoxicity in an ovarian cancer cell line when used at a concentration of 10 µg/ml, with radiolabeled thymidine uptake equal to 102 and 75% of controls after 48 and 120 hours, respectively. Altretamine (100 µg/ml) reduces colony survival in A204 human rhabdomyosarcoma cells in an NADP-dependent manner in the presence of an S-9 hepatic activating mixture. In vivo, altretamine (150 mg/kg) reduces tumor growth in a mouse model of M5076 murine reticulum cell sarcoma. Altretamine (0.5 mM) inhibits glutathione peroxidase 4 (GPX4) and induces accumulation of lipid-reactive oxygen species (ROS) in U-2932 cells without depleting glutathione (GSH) levels, suggesting it is a class II ferroptosis-inducing compound (FIN). It also acts as a chemosterilant in houseflies, preventing hatching and pupation in male and female houseflies when used at a concentration of 0.05%. Formulations of altretamine have been used in the treatment of various cancers.Formal Name: N2,N2,N4,N4,N6,N6-hexamethyl-1,3,5-triazine-2,4,6-triamine. CAS Number: 645-05-6. Synonyms: 2,4,6-Tris(dimethylamino)-1,3,5-triazine, Hexamethylmelamine, HMM, NSC 13875. Molecular Formula: C9H18N6. Formula Weight: 210.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Soluble, Methanol: Slightly Soluble. SMILES: CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1. InChi Code: InChI=1S/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H3. InChi Key: UUVWYPNAQBNQJQ-UHFFFAOYSA-N.