AJ2-30

AJ2-30 is an inhibitor of the endolysosome transporter solute carrier family 15 member A4 (SLC15A4). It is selective for SLC15A4 over SLC15A3 at 5 µM. AJ2-30 reduces increases in IFN-alpha levels induced by the toll-like receptor 9 (TLR9) agonist CPG-2216 in primary human plasmacytoid dendritic cells (IC50 = 1.8 µM). It also inhibits NOD2 signaling mediated by the NOD2 ligand muramyl dipeptide (MDP, Cay-30866) in a reporter assay using A549 cells expressing membrane-localized SLC15A4 (IC50 = 2.6 µM). AJ2-30 reduces increases in IFN-alpha and IL-6 induced by the TLR9 agonist CPG-2006 or the TLR7 agonist R-837 (imiquimod, Cay-14956) in peripheral blood mononuclear cells (PBMCs) isolated from patients with systemic lupus erythematosus (SLE). It reduces IFN-alpha, IFN-beta, and IFN-gamma production induced by a CPG-2216-DOTAP complex in mice when administered at a dose of 50 mg/kg.Formal Name: 9-ethyl-N-(1-methyl-1H-benzimidazol-2-yl)-9H-carbazole-3-methanamin. CAS Number: 2700322-79-6. Molecular Formula: C23H22N4. Formula Weight: 354.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: CCN1C(C(C2=CC=CC=C21)=C3)=CC=C3CNC4=NC5=CC=CC=C5N4C. InChi Code: InChI=1S/C23H22N4/c1-3-27-20-10-6-4-8-17(20)18-14-16(12-13-21(18)27)15-24-23-25-19-9-5-7-11-22(19)26(23)2/h4-14H,3,15H2,1-2H3,(H,24,25). InChi Key: QKZNLVHPKAXDOL-UHFFFAOYSA-N.