Aganodine

Description: Aganodine is a guanidine that activates presynaptic imidazoline receptors. Aganodine inhibits the presynaptic release of norepinephrine through its agonism at imidazoline receptors. Target: Others. Smiles: ClC1=C2C(=C(Cl)C=C1)CN(NC(=N)N)C2. References: Molderings GJ, Bönisch H, Hammermann R, Göthert M, Brüss M. Noradrenaline release-inhibiting receptors on PC12 cells devoid of alpha(2(-)) and CB(1) receptors: similarities to presynaptic imidazoline and edg receptors. Neurochem Int. 2002 Feb,40(2):157-67. PubMed PMID: 11738482.