Aflatoxin B1

Aflatoxin B1 (AFB1) is a genotoxic mycotoxin that has been found in Aspergillus. It induces the formation of DNA adducts in rat liver microsomes. AFB1 induces transversion of guanine to thymine at codon 29 of the p53 tumor suppressor gene, a mutation commonly seen in hepatocellular carcinoma patients living in regions with high levels of aflatoxin contamination, in HepG2 cells. In vivo, AFB1 (50 and 100 µg/kg) induces hepatocellular carcinoma tumor formation in rats.Formal Name: 2,3,6aR,9aS-tetrahydro-4-methoxy-1H,11H-cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione. CAS Number: 1162-65-8. Synonyms: AFB1, HSDB 3453, NSC 529592. Molecular Formula: C17H12O6. Formula Weight: 312.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 12 mg/ml. lambdamax: 223, 265, 360 nm. SMILES: O=C1C2=C(CCC2=O)C3=C(C(C(C=CO4)C4O5)=C5C=C3OC)O1. InChi Code: InChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3. InChi Key: OQIQSTLJSLGHID-UHFFFAOYSA-N.