AFD-21

Description: AFD-21 is a class I antiarrhythmic drug. It binds to sodium channels in their inactivated state and exerts use- and voltage-dependent inhibition of sodium channels with unbinding rates comparable to those of class I antiarrhythmic drugs with moderate kinetics. Target: Others. Smiles: C(=C\C(O)=O)\C(O)=O.C(CCCN(CC(C)C)CC(C)C)(O)(C1=CC=CC=C1)C2=CC=CC=C2. References: Williams LK, Forero JF, Popovic ZB, Phelan D, Delgado D, Rakowski H, Wintersperger BJ, Thavendiranathan P. Patterns of CMR measured longitudinal strain and its association with late gadolinium enhancement in patients with cardiac amyloidosis and its mimics. J Cardiovasc Magn Reson. 2017 Aug 7,19(1):61. doi: 10.1186/s12968-017-0376-0. PubMed PMID: 28784140, PubMed Central PMCID: PMC5545847.