ADX-88178 (trifluoroacetate salt)

A positive allosteric modulator of mGluR4, enhances glutamate-induced intracellular calcium mobilization in HEK293 cells expressing human or rat mGluR4 (EC50s = 3.5 and 9.1 nM, respectively), selective for mGluR4 over mGluR1, mGluR2, mGluR3, mGluR5, mGluR7, and the GABAB receptor at 30 µM, mGluR6 at 10 µM, and mGluR8 (EC50 = 2.2 µM), selective for mGluR4 over a panel of 71 receptors, transporters, enzymes, and ion channels at 10 µM, reverses haloperidol-induced catalepsy in rats at 10 mg/kg, enhances L-DOPA-induced decreases in motor impairments in 6-OHDA-lesioned rats, does not reverse L-DOPA- and benserazide-induced dyskinesia in 6-OHDA-lesioned rats