ADH-1

ADH-1 is a cyclic peptide antagonist of N-cadherin. It inhibits neurite outgrowth in cerebellar neurons cultured on N-cadherin-expressing 3T3 cell monolayers (IC50 = 0.323 mM). ADH-1 (0.2 mg/ml) inhibits cell scattering and motility induced by collagen I in Capan-1 cells and wild-type and N-cadherin-overexpressing BxPC-3 cells. It induces apoptosis in N-cadherin-overexpressing, but not knockdown, BxPC-3 cells when used at a concentration of 1 mg/ml. ADH-1 (50 mg/kg) reduces tumor growth in an N-cadherin-overexpressing BxPC-3 mouse xenograft model.Formal Name: N-acetyl-L-cysteinyl-L-histidyl-L-alanyl-L-valyl-L-cysteinamide, cyclic (1->5)-disulfide. CAS Number: 229971-81-7. Synonyms: N-Ac-CHAVC-NH2. Molecular Formula: C22H34N8O6S2. Formula Weight: 570.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15 mg/mL, DMSO: 30 mg/mL, PBS (pH 7.2): 5 mg/mL. SMILES: O=C1[C@H](C(C)C)NC([C@H](C)NC([C@H](CC2=CN=CN2)NC([C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)N1)=O)=O)=O. InChi Code: InChI=1S/C22H34N8O6S2/c1-10(2)17-22(36)29-15(18(23)32)7-37-38-8-16(27-12(4)31)21(35)28-14(5-13-6-24-9-25-13)20(34)26-11(3)19(33)30-17/h6,9-11,14-17H,5,7-8H2,1-4H3,(H2,23,32)(H,24,25)(H,26,34)(H,27,31)(H,28,35)(H,29,36)(H,30,33)/t11-,14-,15-,16-,17-/m0/s1. InChi Key: FQVLRGLGWNWPSS-BXBUPLCLSA-N.