ACTH (4-11) (human, mouse, rat, porcine, bovine, ovine)

ACTH (4-11) is a peptide fragment of adrenocorticotropic hormone (ACTH, Cay-24257), a peptide hormone found in the brain that is involved in the biological stress response. ACTH (4-11) induces differentiation of melanocytes when used at a concentration of 1,000 nM. It inhibits angiotensin converting enzyme (ACE) activity in homogenized canine lung with an IC50 value of 24 µM. ACTH (4-11) has been used to determine substrate specificity of recombinant H. zea carboxypeptidase B enzyme (CPBHz).Formal Name: L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysine. CAS Number: 67224-41-3. Synonyms: MEHFRWGK-OH. Molecular Formula: C50H71N15O11S. Formula Weight: 1090.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMSO: 10mg/mL, PBS (pH 7.2): 10mg/mL. lambdamax: 281 nm. SMILES: [H]N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(O)=O)=O)=O)CC1=CNC2=C1C=CC=C2)=O)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O)=O)CCSC. InChi Code: InChI=1S/C50H71N15O11S/c1-77-21-18-33(52)43(69)61-36(16-17-42(67)68)46(72)65-40(24-31-26-55-28-59-31)48(74)63-38(22-29-10-3-2-4-11-29)47(73)62-35(15-9-20-56-50(53)54)45(71)64-39(23-30-25-57-34-13-6-5-12-32(30)34)44(70)58-27-41(66)60-37(49(75)76)14-7-8-19-51/h2-6,10-13,25-26,28,33,35-40,57H,7-9,14-24,27,51-52H2,1H3,(H,55,59)(H,58,70)(H,60,66)(H,61,69)(H,62,73)(H,63,74)(H,64,71)(H,65,72)(H,67,68)(H,75,76)(H4,53,54,56)/t33-,35-,36-,37-,38-,39-,40-/m0/s1. InChi Key: ZKBNJKUZBFBIKV-YJXWTMGESA-N.