Acetoacetyl Coenzyme A (sodium salt hydrate)

Description: Acetoacetyl-coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.[1],[2] It is reversibly converted to acetyl-CoA by acetoacetyl-CoA thiolase in the mitochondria. Acetoacetyl-CoA thiolase (T2) deficiency results in a build-up of ketone bodies leading to intermittent ketoacidosis.[3],[4] Acetoacetyl-CoA is also an intermediate in the microbial biosynthesis of polyhydroxybutyrate.[5]. Target: Others. References: Lynen, F., and Ochoa, S. Enzymes of fatty acid metabolism. Biochem. Biophys. Acta. 12(1-2), 299-314 (1953).