Ac-VDVAD-CHO (trifluoroacetate salt)

Ac-VDVAD-CHO is an inhibitor of caspase-2, -3, and -7 (Kis = 3.5, 1, and 7.5 nM, respectively). It inhibits caspase-2 and -3 in cell-based assays with IC50 values of 1,334 and 346 nM, respectively. Ac-VDVAD-CHO (3 µM) inhibits increases in alkaline phosphatase and caspase-2 and -3 activity induced by human recombinant bone morphogenic protein 4 (BMP4) in MC3T3-E1 murine bone marrow stromal cells. It also inhibits BMP4-induced cell cycle arrest at the G0/G1 phase in MC3T3-E1 cells.Formal Name: N-acetyl-L-valyl-L-alpha-aspartyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-L-alaninamide, trifluoroacetate salt. Synonyms: Ac-Val-Asp-Val-Ala-Asp-CHO. Molecular Formula: C23H37N5O10 . XCF3COOH. Formula Weight: 543.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: OC(C[C@H](NC([C@H](C)NC([C@@H](NC([C@H](CC(O)=O)NC([C@@H](NC(C)=O)C(C)C)=O)=O)C(C)C)=O)=O)C=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C23H37N5O10.C2HF3O2/c1-10(2)18(25-13(6)30)23(38)27-15(8-17(33)34)21(36)28-19(11(3)4)22(37)24-12(5)20(35)26-14(9-29)7-16(31)32,3-2(4,5)1(6)7/h9-12,14-15,18-19H,7-8H2,1-6H3,(H,24,37)(H,25,30)(H,26,35)(H,27,38)(H,28,36)(H,31,32)(H,33,34),(H,6,7)/t12-,14-,15-,18-,19-,/m0./s1. InChi Key: CROWZHDWIJEKAB-NVOIZEPQSA-N.