ABT-333

ABT-333 is an inhibitor of hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp, IC50s = 0.0022-0.0107 µM for genotypes 1a and 1b). It is selective for HCV genotype 1 polymerases over genotypes 2, 3, and 4 (IC50s = 0.9->20 µM), as well as human polymerases (IC50s = >100 µM). Formulations containning ABT-333, ombitasvir, paritaprevir, and ritonavir have been used in the treatment of HCV genotype 1 infections.Formal Name: N-[6-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]-2-naphthalenyl]-methanesulfonamide. CAS Number: 1132935-63-7. Synonyms: Dasabuvir. Molecular Formula: C26H27N3O5S. Formula Weight: 493.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF: 30 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 20 mg/ml, DMSO: 20 mg/ml. lambdamax: 244 nm. SMILES: CC(C)(C)C1=C(OC)C(C2=CC3=CC=C(NS(C)(=O)=O)C=C3C=C2)=CC(N4C=CC(NC4=O)=O)=C1. InChi Code: InChI=1S/C26H27N3O5S/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18/h6-15,28H,1-5H3,(H,27,30,31). InChi Key: NBRBXGKOEOGLOI-UHFFFAOYSA-N.